The Alpine A220 was a sports prototype from 1968 and 1969 that took part in a number of sports car races.

The Alpine A220 was fitted with a special engine. Gordini combined two 1.5-litre 4-cylinder engines to form a conventional V8 engine. In the first variant, the unit received four Weber carburettors, which were replaced in 1969 by fuel-injection. The V8 engine with carburettors delivered 228 kW (310 hp), the fuel-injection engine 257 kW (350 hp). The cars were fitted with a 5-speed ZF gearbox.

The chassis and body were taken from the A210 and adapted so that the heavy and wider engine could be integrated into the chassis.

The A220 made its debut in the spring of 1968 in France. It quickly became apparent that the car was underpowered for the 3-litre class. The faster and heavier A220 tended to oversteer, compared to the A210.

At Le Mans in 1968, four A220 started the race. Only one, driven by André de Cortanze and Jean Vinatier crossed the finish line.