Driver: San Francisco is a sandbox-style action-adventure driving video game developed by Ubisoft Reflections and published by Ubisoft. The game formally was unveiled at E3 2010 and was released in Australia on September 1, 2011, Europe on September 2, 2011 and North America on September 6, 2011 on PlayStation 3 and Xbox 360, while the Microsoft Windows version was released on 27 September 2011
The game takes place six months after the events of Driv3r with both John Tanner and Charles Jericho surviving the shootout in Istanbul and Jericho escaping to San Francisco. Tanner and his partner Tobias Jones, have pursued him there and Jericho is finally arrested. Jericho is shown being transported in the back of a prison truck, but manages to escape with help of hired assassin Leila Sharan, who hijacks a KEOC news chopper and fires an RPG at the convoy, and a vial of acid hidden within his mouth by a paid off guard. He overpowers the guards, and hijacks the truck. Tanner and Jones witness this from Tanner's car, pursuing Jericho as he causes havoc on the streets of the city. Tanner ends driving in front of Jericho in an alleyway, who, using the truck rams Tanner's car into the path of a tractor trailer, resulting in a devastating crash, putting him into a coma.
Whilst in a coma dream, Tanner soon discovers his ability to "shift" into another person's body, retaining his persona but, to everyone else, looking and sounding exactly the same as the person he has shifted into. Using this confusing power, Tanner helps some teenagers win street races to get money for college fees, aids some vigilante ex-cops remove fake medicine from circulation and lends his driving abilities to police officers hunting down criminals whilst trying to figure out Jericho's plan. After deducing that Jericho is after the materials to create a cyanide gas bomb, he shifts into Ordell, a low-time crook looking to rise up through Jericho's organization.
Tanner later, however, discovers that Jericho can also shift, and realises that when he is not in his body, Jericho can take over. He is deconspired, when disguised as Ordell, drives Leila to her target, which is his body. Eventually, Tanner comes to notice that he is in a dream world when the strange messages from the real world creep into his mind. Jericho's powers become more potent, but as it is in Tanner's head, he is over-powered and defeated when Tanner assumes control of his mental projection of the city. In a mental visualisation of a police interrogation room, Tanner begins questioning his mental projection of Jericho and figures that the news reports from the television in his real-world hospital bed are feeding his coma dream. From this he knows of a real-world bomb plot, but deduces that it is not real - Jericho is a gangster, not a terrorist.
Finally waking up, Tanner requests his car keys from Jones, who reminds him of the truck that hit his Dodge Challenger. Leaving in Jones' Chevrolet Camaro and heading for downtown San Francisco, which is being evacuated due to a bomb threat, a massive cloud of gas erupts. Driving into it, Tanner finds escaping convicts, confirming his theory that it was not a real terror threat. Jericho made a deal with a prisoner for US$30 million to break him out of jail. The 'bomb' was in fact a smokescreen. After a pursuit, Tanner sees Jericho head into the docks. Whilst at first appearing to be a game of chicken and a potential head-on collision, Jones appears in a police SUV and rams Jericho. Tanner claims that he knew what he was doing, but Jones reminds him whose car he was driving before suggesting a well-deserved beer.