The Matra MS680 was a sports car prototype used by the Matra in 1974 at the 24-hour Le Mans race.

The MS680 was the last sports car which was developed at Matra. The only MS680 was based on a converted MS670C chassis. The engine was a 3-litre Matra-12-cylinder unit. The car received a new body that was edgier than on previous prototypes.

The MS680 was extensively tested before the Le Mans race and achieved pleasing times. However, the car was not faster than the MS670C. Originally they had planned for to convert a second-MS670 chassis, after testing it was decided not to be. Matra had some problems with the engine temperature , which led to failure after 104 laps.

Matra pulled out of international motorsport at the end of 1974. Today the Matra MS680 is the Musée de Ville in Romorantin-Lanthenay.