The Wolseley 16/45 was a midsized car that Wolseley brought out in 1927 as the first six-cylinder car with an overhead camshaft.

Its six-cylinder engine had a displacement of 2,025 cm³. The car had a wheelbase of 2,972 mm. Its body was 4,445 mm long, 1,791 mm wide and its chassis (without construction) weighed 914 kg.

Its maximum speed was 95 km/h.